Conwy and Denbighshire will go into lockdown on Thursday at 6pm.
Local lockdowns will also be imposed in Wrexham and Flintshire.
READ These are the lockdown restrictions for North Wales counties
Health Minister Vaughan Gething has just made the announcement to the Senedd.
He said the decision followed a meeting he and FIrst Minister Mark Drakeford had with local authorities and police.
Vaughan Gething today
Mr Gething said: “Unfortunately, we have seen a rise in coronavirus cases in four north Wales local authority areas – in Denbighshire, Flintshire, Wrexham and Conwy.
“These are largely linked to people socialising indoors and are the pattern of transmission similar to what we have seen in South Wales.
“We have worked closely with local authority leaders and the police in North Wales and we all agree about the need to take swift action to control the spread of the virus.”
Under the rules, nobody is able to enter or leave the counties without a "reasonable excuse".
READ Two students at Wrexham's Glyndwr University test positive for coronavirus
Exceptions include travelling to school or to work if you are unable to work from home.
People can travel to buy food and medical supplies, seek medical assistance or go to the vets, and move home.
Gwynedd and Anglesey will not be included in the lockdowns at this stage.
Mr Gething said there were no plans for no more restrictions on a national level.
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